Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

84 questions · 86 findings · 8 reviews

No studies found 9 · 10.5%GRADE not reported 5 · 5.8%Very low 12 · 14%Low 28 · 32.6%Moderate 23 · 26.7%High 9 · 10.5%

Dopamine agonist vs levodopa

Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · patients with restless legs syndrome

Summary of findings: dopamine agonists showed no clear difference in clinical Global Impressions ‐ Improvement of condition (CGI‐I)… compared with levodopa (moderate certainty).

1 finding from 1 review

Dopamine agonist vs levodopa

Number of participants reporting an adverse event · patients with restless legs syndrome

Summary of findings: dopamine agonists showed no clear difference in number of patients experiencing adverse events compared with levodopa (moderate certainty).

1 finding from 1 review

Dopamine agonist vs placebo

Withdrawals due to adverse events · patients with restless legs syndrome according to IRLSSG, 18 years or older

Summary of findings: dopamine agonists leads to higher number of dropouts due to adverse events compared with placebo (high certainty).

1 finding from 1 review

Dopamine agonist vs placebo

Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · patients with restless legs syndrome according to IRLSSG, 18 years or older

Summary of findings: dopamine agonists leads to higher clinical Global Impressions ‐ Improvement of condition (CGI‐I)… compared with placebo (high certainty).

1 finding from 1 review