Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

34 questions · 44 findings · 8 reviews

No studies found 3 · 6.8%GRADE not reported 40 · 90.9%Very low 0 · 0%Low 0 · 0%Moderate 1 · 2.3%High 0 · 0%

High-intensity sweeteners other than stevia (aspartame, sucralose, saccharin) in food products vs Any comparator (dietary sugar, no treatment, or other sweetener)

Effects of non-stevia high-intensity sweeteners (aspartame, sucralose, saccharin) on cariogenic bacteria in dental plaque or saliva · healthy people

No eligible studies evaluated high-intensity sweeteners such as aspartame, sucralose, or saccharin for their effect on cariogenic bacteria.

1 finding from 1 review

Fluoride-containing dental care products (mainly fluoride toothpaste) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies)

In children in low-fluoridated tap water areas, dental care products contributed on average 39% of total fluoride exposure (ungraded).

5 findings from 1 review
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Fluoride-containing dental care products (mainly fluoride toothpaste) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Adults using fluoride-containing dental care products (two included studies [28,47]; aged 20-35)

In adults in poor-fluoridated tap water areas, dental care products contributed on average 12% of total fluoride exposure (ungraded; 1-2 studies).

3 findings from 1 review

Fluoride-containing dental care products (mainly fluoride toothpaste; one study also included fluoride varnish) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI) · Humans using fluoride-containing dental care products; 28 included studies, mostly young children, only two studies in adults (aged…

Fluoride-containing dental care products (mainly toothpaste) contributed on average 38% (SD 27%) of total daily fluoride intake, regardless of tap-water fluoride level or age (ungraded; descriptive synthesis, no meta-analysis).

1 finding from 1 review

Fluoride-containing dental care products (mainly fluoride toothpaste) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total fluoride exposure · Pregnant and lactating women

No study has explored the contribution of dental care products to total fluoride exposure in pregnant and lactating women.

1 finding from 1 review

Sealing (resin sealant, glass ionomer cement, or polyurethane tape) vs Non-invasive / control treatment

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition)

Sealing probably reduces the odds of proximal lesion progression compared with placebo (OR 0.27, 95% CI 0.18 to 0.42; moderate certainty).

1 finding from 1 review