Findings

What do systematic reviews say?

23 questions · 23 findings · 3 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 17.4%Low 10 · 43.5%Moderate 5 · 21.7%High 4 · 17.4%

Usual care vs immunosuppressive withdrawal after combination therapy

Relapse · Participants with Crohn's disease in remission

Usual care showed no clear difference in relapse at 12 or 24 months compared with immunosuppressive withdrawal after combination therapy (low certainty).

1 finding from 1 review

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease 2018 · Cochrane Headline outcomes only
RR 1.02 [0.68, 1.52]
2 studies · 111 participants
Low

Usual care vs immunosuppressive withdrawal after combination therapy

Adverse events · Participants with Crohn's disease in remission

Usual care showed no clear difference in adverse events compared with immunosuppressive withdrawal after combination therapy (low certainty).

1 finding from 1 review

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease 2018 · Cochrane Headline outcomes only
RR 1.11 [0.44, 2.81]
2 studies · 111 participants
Low

Usual care vs immunosuppressive withdrawal after combination therapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after combination therapy (very low certainty).

1 finding from 1 review

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease 2018 · Cochrane Headline outcomes only
RR 1 [0.21, 4.66]
1 study · 80 participants
Very low