Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

186 questions · 190 findings · 17 reviews · Haematology

No studies found 47 · 24.7%GRADE not reported 21 · 11.1%Very low 26 · 13.7%Low 47 · 24.7%Moderate 37 · 19.5%High 12 · 6.3%

Intervention not reported

All‐cause mortality at 31 to 100 days · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

It is very uncertain whether the intervention changes all‐cause mortality at 31 to 100 days (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with any bleeding ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Length of hospital admission ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Hospital readmission rate ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Number of participants with any bleeding (0 to 3 months) · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The intervention showed no clear difference in number of participants with any bleeding (0 to 3 months) (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with clinically significant bleeding (0 to 3 months) · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The intervention showed no clear difference in number of participants with clinically significant bleeding (0 to 3… (low certainty).

1 finding from 1 review

Intervention not reported

Serious infections (0 to 3 months) · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The intervention showed no clear difference in serious infections (0 to 3 months) (low certainty).

1 finding from 1 review

Intervention not reported

Hospital readmission (0 to 3 months) · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The intervention showed no clear difference in hospital readmission (0 to 3 months) (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Relapse, progression or death (calculated instead of PFS) · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP probably leads to lower progression, relapse or death compared with chemotherapy including ABVD (moderate certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: treatment‐related mortality · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP showed no clear difference in adverse event: treatment‐related mortality compared with chemotherapy including ABVD (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: secondary malignancies · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP showed no clear difference in adverse event: secondary malignancies compared with chemotherapy including ABVD (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: secondary malignancies: AML or MDS · Patients with early unfavourable or advanced stage HL

Escalated BEACOPP may leads to higher adverse event: secondary malignancies: AML or MDS compared with chemotherapy including ABVD (low certainty).

1 finding from 1 review

Escalated BEACOPP vs chemotherapy including ABVD

Adverse event: infertility (secondary amenorrhoea) · Patients with early unfavourable or advanced stage HL

It is very uncertain whether escalated BEACOPP changes adverse event: infertility (secondary amenorrhoea) compared with chemotherapy including ABVD (very low certainty).

1 finding from 1 review