Findings

What do systematic reviews say?

26 questions · 26 findings · 2 reviews · Kidney and Transplant

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 12 · 46.2%Low 10 · 38.5%Moderate 4 · 15.4%High 0 · 0%

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Relapse · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in relapse Time frame: 6 to 12 months compared with oral steroids alone (moderate certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.73 [0.51, 1.03]
7 studies · 422 participants
Moderate

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: diabetes or hyperglycaemia · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: diabetes or hyperglycaemia compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.48 [0.19, 1.25]
7 studies · 450 participants
Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: obesity or Cushing's Syndrome · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids may leads to lower adverse effects: obesity or Cushing's Syndrome compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.11 [0.02, 0.59]
5 studies · 388 participants
Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse events: hypertension · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse effects: hypertension compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.86 [0.23, 3.2]
3 studies · 219 participants
Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Acute kidney injury · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in adverse events: acute kidney injury compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 1.78 [0.35, 8.99]
4 studies · 270 participants
Low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Adverse effects: acne · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids may leads to lower adverse effects: acne compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.15 [0.03, 0.67]
4 studies · 270 participants
Low