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What do systematic reviews say?

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Evidence found and GRADE certainty

42 questions · 42 findings · 3 reviews · Drugs and Alcohol

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No studies found 17 · 40.5%GRADE not reported 0 · 0%Very low 18 · 42.9%Low 0 · 0%Moderate 3 · 7.1%High 4 · 9.5%

Baclofen vs placebo

Global improvement · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs placebo

Craving · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs placebo

AEs · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs placebo

Severe AEs · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs placebo

Leaving the study early · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs placebo

Dropouts due to adverse events · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs placebo

Relapse: return to any drinking at end of treatment · alcohol use disorder

Summary of findings table ‐ Baclofen probably leads to lower relapse: return to any drinking at end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Baclofen vs acamprosate

Dropout · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts at end of treatment compared with acamprosate (very low certainty).

1 finding from 1 review

Baclofen vs acamprosate

Dropouts due to adverse events · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts due to adverse events compared with acamprosate (very low certainty).

1 finding from 1 review

Baclofen vs naltrexone

Relapse: return to any drinking at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes relapse: return to any drinking at end of treatment compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen vs naltrexone

Adverse events: number of participants with ≥ 1 adverse event at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes adverse events: number of participants with ≥ 1 adverse event at end… compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen vs naltrexone

Dropout · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts at end of treatment compared with naltrexone (very low certainty).

1 finding from 1 review

Baclofen vs placebo

Frequency of use % of heavy drinking days at the end of treatment · alcohol use disorder
1 finding from 1 review

Baclofen vs placebo

Adverse events: number of participants with ≥ 1 adverse event at end of treatment · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in adverse events: number of participants with ≥ 1 adverse event at end… compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs placebo

Dropout · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in dropouts at end of treatment compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs placebo

Dropouts due to adverse events · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in dropouts due to adverse events compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs acamprosate

Relapse: return to any drinking at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes relapse: return to any drinking at end of treatment compared with acamprosate (very low certainty).

1 finding from 1 review