Findings

What do systematic reviews say?

26 questions · 26 findings · 1 reviews · Dementia and Cognitive Improvement

No studies found 10 · 38.5%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 11.5%Moderate 9 · 34.6%High 4 · 15.4%

Cognitive decline from baseline · people with MCI

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Activities of daily living · people with MCI

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1457 participants
Moderate

Health‐related quality of life · people with MCI

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Incidence of Alzheimer's disease · cognitively healthy people in late life

Other NSAIDs showed no clear difference in incidence of Alzheimer's disease compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.91 [0.89, 4.1]
1 study · 2125 participants
Moderate

Adverse events: myocardial infarction · cognitively healthy people in late life

Other NSAIDs showed no clear difference in adverse events –myocardial infarction compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.21 [0.61, 2.4]
1 study · 2500 participants
Moderate

Adverse effects ‐ Stroke · cognitively healthy people in late life

Other NSAIDs showed no clear difference in adverse events – stroke compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.82 [0.76, 4.37]
1 study · 2500 participants
Moderate