Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

158 questions · 167 findings · 20 reviews · Headline outcomes only

No studies found 40 · 24%GRADE not reported 14 · 8.4%Very low 45 · 26.9%Low 33 · 19.8%Moderate 30 · 18%High 5 · 3%

Aspirin vs placebo

Total mortality · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin showed no clear difference in total mortality compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Cardiovascular mortality · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin showed no clear difference in cardiovascular mortality compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Non‐fatal cardiovascular events · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin may leads to lower non‐fatal cardiovascular events compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Major bleedinga · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin leads to higher major bleedinga compared with placebo (high certainty).

1 finding from 1 review

Aspirin vs placebo

Cardiovascular events · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin may leads to lower all cardiovascular events compared with placebo (low certainty).

1 finding from 1 review

Heparin plus aspirin vs aspirin

Adverse events in the mother ‐ Bleeding · women with persistent antiphospholipid antibodies and recurrent pregnancy loss

Heparin plus aspirin showed no clear difference in adverse events in the mother ‐ Bleeding compared with aspirin (low certainty).

1 finding from 1 review