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What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 22 findings · 7 reviews · Common Mental Disorders

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No studies found 1 · 4.5%GRADE not reported 0 · 0%Very low 12 · 54.5%Low 7 · 31.8%Moderate 2 · 9.1%High 0 · 0%

Lamotrigine vs lithium

Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder

Lamotrigine showed no clear difference in recurrence of any episodes at one year for clinical worsening with… compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder

Lamotrigine probably leads to lower recurrence of any episodes at one year for clinical worsening with… compared with placebo (moderate certainty).

1 finding from 1 review