Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

48 questions · 48 findings · 3 reviews · Stroke

No studies found 7 · 14.6%GRADE not reported 0 · 0%Very low 7 · 14.6%Low 17 · 35.4%Moderate 11 · 22.9%High 6 · 12.5%

Dual vs one antiplatelet agent

Stroke, myocardial infarction, or vascular death · preventing early recurrence after ischaemic stroke or TIA

Dual probably leads to lower stroke, myocardial infarction, or vascular death compared with one antiplatelet agent (moderate certainty).

1 finding from 1 review

Multiple vs fewer antiplatelet agents

Stroke, myocardial infarction, or vascular death · preventing early recurrence after ischaemic stroke or TIA

Multiple probably leads to lower stroke, myocardial infarction, or vascular death compared with fewer antiplatelet agents (moderate certainty).

1 finding from 1 review

NOAC (rivaroxaban) vs vitamin K antagonist (VKA)

Thromboembolic events · people with antiphospholipid syndrome and a history of stroke or thromboembolic events

NOAC (rivaroxaban) showed no clear difference in any thromboembolic event compared with standard‐dose VKA (moderate certainty).

1 finding from 1 review

Anticoagulant drugs: VKA high dose vs vitamin K antagonist (VKA)

Total mortalitya · people with antiphospholipid syndrome and a history of stroke or thromboembolic events

High‐dose VKA showed no clear difference in all‐cause mortalitya compared with standard‐dose VKA (low certainty).

1 finding from 1 review

Anticoagulant drugs: VKA high dose vs vitamin K antagonist (VKA)

Any bleedingb · people with antiphospholipid syndrome and a history of stroke or thromboembolic events

High‐dose VKA showed no clear difference in any bleedingb compared with standard‐dose VKA (low certainty).

1 finding from 1 review