Findings

What do systematic reviews say?

28 questions · 28 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 28 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)

No meta-analysis was conducted; seven included studies reported inhibition of Streptococcus mutans growth with cranberry extract or fractions.

1 finding from 1 review

Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)

Grape seed extract inhibits S. mutans growth in vitro (MIC ~0.5 mg/mL to 250 mg/mL across 5 studies; ungraded).

1 finding from 1 review

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a… 2024 All outcomes
in vitro (laboratory)
GSE inhibited S. mutans growth across ~0.5-250 mg/mL (Abstract): inhibition at 250-500 mg/mL (Swadas), 4 mg/mL (Zhao), MIC 1000 ug/mL and MBC 4000 ug/mL (Furiga), MIC 0.5 mg/mL (Smullen), and MIC 19.07 mg/mL for…
5 studies
GRADE not reported

Bacterial adhesion or initial colonization · Streptococcus mutans (in vitro cultures and biofilms)

No meta-analysis was conducted; three included studies reported reduced adhesion or initial colonization with cranberry extract or fractions.

1 finding from 1 review

Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract inhibits S. mutans adhesion / initial colonization in vitro (3 studies; ungraded).

1 finding from 1 review

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a… 2024 All outcomes
in vitro (laboratory)
Cranberry formulations adhered to and prevented biofilm on saliva-coated hydroxyapatite (Greene); reduced adhesion via inhibited glucan synthesis (Feng); reduced initial S. mutans colonization 40-60% through reduced…
3 studies
GRADE not reported

Cell death / cytotoxicity induction · Streptococcus mutans (in vitro cultures and biofilms)

One study reported time-dependent cell-death induction (50% at 10 h) with cranberry extract (ungraded).

1 finding from 1 review

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a… 2024 All outcomes
in vitro (laboratory)
Cranberry extract produced a time- and concentration-dependent reduction in bacterial count, with a 50% reduction after 10 h (Singhal).
1 study
GRADE not reported

Biofilm morphology or biomass · Streptococcus mutans (in vitro cultures and biofilms)

No meta-analysis was conducted; four included studies reported disrupted biofilm structure or reduced biomass with cranberry extract or fractions.

1 finding from 1 review

Bacterial adhesion · Streptococcus mutans (in vitro cultures and biofilms)

No meta-analysis was conducted; two included studies reported reduced Streptococcus mutans adhesion with grape seed extract or fractions.

1 finding from 1 review

Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)

No meta-analysis was conducted; one included study reported antioxidant properties of cranberry fractions.

1 finding from 1 review