Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 4 reviews

No studies found 1 · 4.2%GRADE not reported 14 · 58.3%Very low 7 · 29.2%Low 1 · 4.2%Moderate 0 · 0%High 1 · 4.2%

FLUPENTHIXOL DECANOATE VERY LOW (˜6 mg/IM) DOSE vs FLUPENTHIXOL DECANOATE LOW DOSE (˜9 mg/IM)

Adverse effects: general ‐ movement disorders ‐ requiring anticholinergic medication ‐ short/medium term ‐ not reported · patients with schizophrenia or related psychoses

The review found no eligible studies for this question.

1 finding from 1 review

FLUPENTHIXOL DECANOATE vs GENERAL ORAL ANTIPSYCHOTICS

Adverse effects: general ‐ movement disorders ‐ requiring anticholinergic medication ‐ short term Numbers requiring anticholinergic medication · patients with schizophrenia or related psychoses

It is very uncertain whether FLUPENTHIXOL DECANOATE changes adverse effects: general ‐ movement disorders ‐ requiring… compared with ORAL ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs placebo

Requirement for anticholinergics number of participants requiring medication for extrapyramidal side effects · patients with an acute manic or mixed episode

Aripiprazole leads to higher requirement for anticholinergics number of participants requiring… compared with placebo (high certainty).

1 finding from 1 review