Findings

What do systematic reviews say?

72 questions · 72 findings · 6 reviews · Skin

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No studies found 20 · 27.8%GRADE not reported 0 · 0%Very low 15 · 20.8%Low 23 · 31.9%Moderate 12 · 16.7%High 2 · 2.8%

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Assessment of erythema or telangiectasia · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Time needed until improvement · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Famciclovir vs placebo

Incidence of herpes labialis during use of the preventative intervention (by clinical evaluation) ‐ famciclovir 125 mg · participants with recurrent herpes labialis

Famciclovir showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
RR 0.74 [0.5, 1.11]
1 study · 120 participants
Moderate

Famciclovir vs placebo

Duration of attack of recurrent herpes labialis during use of the preventative intervention ‐ famciclovir 125 mg · participants with recurrent herpes labialis

Famciclovir showed no clear difference in duration of attack of recurrent herpes labialis during use of the… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
HR 1.63 [0.84, 3.15]
1 study · 47 participants
Moderate

Finasteride 5 mg to 7.5 mg vs placebo

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 54 participants
Very low

Finasteride 5 mg to 7.5 mg vs placebo

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg to 7.5 mg vs placebo

Proportion of participants who reported an adverse event · women with hirsutism

It is very uncertain whether finasteride 5 mg to 7.5 mg changes proportion of participants who reported an adverse event compared with placebo (very low certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 1.13 [0.48, 2.67]
3 studies · 67 participants
Very low

Finasteride 5 mg to 7.5 mg vs placebo

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 62 participants
Very low

Finasteride 5 mg to 7.5 mg vs placebo

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 52 participants
Low

Finasteride 5 mg to 7.5 mg vs placebo

Change in BMI · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Finasteride 5 mg to 7.5 mg vs placebo

Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg vs spironolactone 100 mg

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Low

Finasteride 5 mg vs spironolactone 100 mg

Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Finasteride 5 mg vs spironolactone 100 mg

Proportion of participants who reported an adverse event · women with hirsutism

Finasteride 5 mg showed no clear difference in proportion of participants who reported an adverse event compared with spironolactone 100 mg (moderate certainty).

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
RR 0.2 [0.03, 1.41]
1 study · 20 participants
Moderate

Finasteride 5 mg vs spironolactone 100 mg

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Low

Finasteride 5 mg vs spironolactone 100 mg

Change in serum androgen levels · women with hirsutism

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 34 participants
Low

Finasteride 5 mg vs spironolactone 100 mg

Change in BMI ‐ not measured · women with hirsutism

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found