What do systematic reviews say?

Starting administration of the progestogen earlier vs starting administration of the progestogen later

It is very uncertain whether starting administration of the progestogen earlier changes miscarriage Rate compared with starting administration of the progestogen later (very low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 0.45 [0.16, 1.25]
  1 study · 191 participants
  Very low

Starting administration of the progestogen earlier vs starting administration of the progestogen later

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 282 participants
  Very low

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Starting administration of the progestogen earlier probably leads to lower cycle cancellation rate compared with starting administration of the progestogen later (moderate certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 0.28 [0.11, 0.74]
  1 study · 282 participants
  Moderate

Starting administration of the progestogen earlier vs starting administration of the progestogen later

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs control

GnRH agonists may leads to higher live birth rate compared with control (low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 2.62 [1.19, 5.78]
  1 study · 234 participants
  Low

Stimulated cycle vs programmed

It is very uncertain whether stimulated cycle changes miscarriage rate compared with programmed (very low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 0.79 [0.36, 1.71]
  3 studies · 355 participants
  Very low

GnRH agonists vs control

GnRH agonists showed no clear difference in clinical pregnancy rate compared with control (low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 1.08 [0.82, 1.43]
  8 studies · 1289 participants
  Low

GnRH agonists vs control

GnRH agonists showed no clear difference in miscarriage rate compared with control (low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 0.85 [0.36, 2]
  4 studies · 828 participants
  Low

GnRH agonists vs control

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs control

GnRH agonists showed no clear difference in cycle cancellation cycles compared with control (low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 0.49 [0.21, 1.17]
  2 studies · 530 participants
  Low

GnRH agonists vs control

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs placebo

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs placebo

It is very uncertain whether among different GnRH agonists changes clinical pregnancy rate compared with placebo (very low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 1.93 [0.62, 5.98]
  1 study · 50 participants
  Very low

GnRH agonists vs placebo

It is very uncertain whether among different GnRH agonists changes miscarriage rate compared with placebo (very low certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 1.33 [0.36, 4.87]
  1 study · 68 participants
  Very low

GnRH agonists vs placebo

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Stimulated cycle vs programmed

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs placebo

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs placebo

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs GnRH antagonists

The review found no eligible studies for this question.

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonists vs GnRH antagonists

GnRH agonists probably leads to lower clinical pregnancy rate compared with gnRH antagonists (moderate certainty).

• Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
  OR 0.62 [0.42, 0.9]
  1 study · 473 participants
  Moderate