Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 11,779 findings · 747 reviews · Headline outcomes only

No studies found 3,205 · 27.2%GRADE not reported 628 · 5.3%Very low 3,261 · 27.7%Low 2,913 · 24.7%Moderate 1,453 · 12.3%High 319 · 2.7%

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Active stimulation vs Placebo (sham/placebo device)

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse event: lead failure/ displacement · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Participant‐reported pain relief of 50% or greater · adults with chronic pain

It is very uncertain whether active stimulation + other intervention changes pain intensity. Proportion with ≥ 50% pain relief. compared with other intervention alone (very low certainty).

1 finding from 1 review

Active stimulation + other intervention vs other intervention alone

Adverse event: lead failure/ displacement · adults with chronic pain

The review found no eligible studies for this question.

3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity (number of people with ≥ 50% improvement) · adults with chronic pain

Active stimulation + other intervention may leads to higher pain intensity. Proportion with ≥50% pain relief. compared with other intervention alone (low certainty).

2 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse events: infection · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review