Findings

What do systematic reviews say?

3,971 questions · 9,849 findings · 853 reviews

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No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The pooled odds ratio was 0.99 (95% CI 0.81 to 1.23).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Overall (n=4)
OR 0.99 [0.81, 1.23]
4 studies · 2662 participants
GRADE not reported

Intervention not reported

Marginal integrity success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Rubber dam isolation: Yes
Proportion 0.883 [0.782, 0.941]
10 studies
GRADE not reported

Intervention not reported

Absence of recurrent caries success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Material type: Resin-based material + self-etching adhesion
Proportion 0.924 [0.847, 0.963]
8 studies
GRADE not reported

Intervention not reported

Anatomic form success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Material type: Resin-based material + total-etching adhesion
Proportion 0.919 [0.821, 0.966]
7 studies
GRADE not reported

T allele of AMELX rs946252 vs C allele

Dental caries susceptibility · Ethnicity: Mixed (n=1) individuals with caries/high caries and controls

The pooled odds ratio was 0.99 (95% CI 0.53 to 1.86).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Mixed (n=1)
OR 0.99 [0.53, 1.86]
1 study
GRADE not reported

G allele of LTF rs1126478 vs A allele

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The pooled odds ratio was 0.98 (95% CI 0.87 to 1.10).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Overall (n=4)
OR 0.98 [0.87, 1.10]
4 studies · 2662 participants
GRADE not reported

Intervention not reported

Marginal integrity success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Material type: Open sandwich restoration
Proportion 0.940 [0.695, 0.991]
1 study
GRADE not reported

LTF rs1126477 variant vs Reference allele/genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

LTF rs11216477 was significantly associated with dental caries in a single study (OR 1.17, 95% CI 1.06 to 1.29; ungraded).

1 finding from 1 review

The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes
China · Single study (Wang et al. 2018)
OR 1.17 [1.06, 1.29]
1 study · 910 participants
GRADE not reported

CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype

Dental caries susceptibility · Ethnicity: Asian (n=1) individuals with caries/high caries and controls

The pooled odds ratio was 0.89 (95% CI 0.04 to 22.53).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Asian (n=1)
OR 0.89 [0.04, 22.53]
1 study
GRADE not reported

T allele of AMELX rs17878486 vs C allele

Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls

The pooled odds ratio was 2.87 (95% CI 0.35 to 23.23).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Caucasian (n=2)
OR 2.87 [0.35, 23.23]
2 studies
GRADE not reported

Intervention not reported

Marginal integrity success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Use of cavity conditioner: Yes
Proportion 0.857 [0.737, 0.928]
10 studies
GRADE not reported

TT genotype of ENAM rs3796703 vs CC genotype

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The pooled odds ratio was 5.22 (95% CI 0.25 to 108.96).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Overall (n=2)
OR 5.22 [0.25, 108.96]
2 studies · 1152 participants
GRADE not reported

T allele of AMELX rs6639060 vs C allele

Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls

The pooled odds ratio was 1.08 (95% CI 0.63 to 1.85).

1 finding from 1 review

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes
Ethnicity: Caucasian (n=1)
OR 1.08 [0.63, 1.85]
1 study
GRADE not reported

Intervention not reported

Absence of recurrent caries success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Study design: Noncontrolled trial
Proportion 0.942 [0.837, 0.981]
4 studies
GRADE not reported

Intervention not reported

Anatomic form success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Use of cavity conditioner: Yes
Proportion 0.896 [0.779, 0.955]
9 studies
GRADE not reported

rs1126478, additive (per-allele) model vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The additive-model association remained non-significant after excluding the adult-data study (OR 1.47, 95% CI 0.92 to 2.35; ungraded).

1 finding from 1 review

The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes
Brazil; European countries; China · Sensitivity analysis excluding the study using adult data (Fine 2013)
OR 1.47 [0.92, 2.35]
3 studies · 1752 participants
GRADE not reported

Intervention not reported

Marginal integrity success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Use of coat: No
Proportion 0.916 [0.803, 0.966]
7 studies
GRADE not reported

G allele of LTF rs1126478 vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under an allelic model (OR 1.41, 95% CI 0.48 to 4.13; ungraded).

1 finding from 1 review

The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes
Brazil; United States; European countries; China · Allelic model (G vs. A)
OR 1.41 [0.48, 4.13]
4 studies · 1802 participants
GRADE not reported

Intervention not reported

Absence of recurrent caries success rate

1 finding from 1 review

Success rate of proximal tooth-coloured direct restorations in primary teeth at 24 months: a meta-analysis. 2020 All outcomes
Dentist experience: Experienced
Proportion 0.908 [0.861, 0.941]
28 studies
GRADE not reported

Organised inpatient (stroke unit) care vs alternative service

Poor outcome by the end of scheduled · adults with acute stroke

Organised inpatient (stroke unit) care probably leads to lower poor outcome by the end of scheduled compared with alternative service (moderate certainty).

1 finding from 1 review

Organised inpatient (stroke unit) care for stroke: network meta‐analysis 2020 · Cochrane Headline outcomes only
OR 0.77 [0.69, 0.87]
26 studies · 5336 participants
Moderate