Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Sulthiame vs levetiracetam

Gastrointestinal adverse events · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (gastrointestinal) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (bones and muscles) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (bones and muscles) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (others) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (others) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

All adverse effects · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in all adverse effects compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Paraesthesia · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in paraesthesia compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Dizziness · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in dizziness compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Headache · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in headache compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Anorexia · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in anorexia compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Rash · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in rash compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Gingival hyperplasia · participants with epilepsy (GTCS)

Sulthiame may leads to lower gingival hyperplasia compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Other · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in other compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Treatment withdrawal · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in treatment withdrawal compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Seizure freedom · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in seizure freedom compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (general symptoms) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (general symptoms) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (central nervous system) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (central nervous system) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (behaviour) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (behaviour) compared with levetiracetam (low certainty).

1 finding from 1 review