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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

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No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator

Anatomic form success rate · Children with primary molars requiring proximal (Class II) restorations

The pooled 24-month anatomic form success rate was 0.901 (95% CI 0.845-0.938; ungraded).

1 finding from 1 review

T allele of ENAM rs3796703 vs C allele of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of ENAM rs3796703 and dental caries susceptibility (T vs C model: OR 0.92, 95% CI 0.24-3.58); certainty not graded.

1 finding from 1 review

TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs17878486 and dental caries susceptibility (TT vs CC + CT model: OR 6.17, 95% CI 0.41-92.05) in the Ethnicity: Caucasian subgroup; certainty not graded.

7 findings from 1 review
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CT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs6639060 and dental caries susceptibility (CT vs CC model: OR 1.27, 95% CI 0.49-3.30) in the Age group: Adults subgroup; certainty not graded.

1 finding from 1 review

Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

After excluding the high-risk-of-bias study (Bravo 1996), fluoride varnish and fissure sealant did not differ in caries incidence of FPMs and heterogeneity fell to 0% (RR 1.05, 95% CI 0.91 to 1.22; 5 RCTs; ungraded).

2 findings from 1 review

AG + GG genotype (G-allele carriers) of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG + GG vs AA model: OR 0.24, 95% CI 0.03-2.17) in the Ethnicity: Mixed subgroup; certainty not graded.

3 findings from 1 review

GG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of LTF rs1126478 and dental caries susceptibility (GG vs AA model: OR 0.97, 95% CI 0.73-1.29) in the Ethnicity: Asian subgroup; certainty not graded.

2 findings from 1 review

TT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs17878486 and dental caries susceptibility (TT vs CC model: OR 5.12, 95% CI 0.09-278.85) in the Control group: Caries-free subgroup; certainty not graded.

4 findings from 1 review
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Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Caries incidence (proportion of enrolled children developing dentin caries, ICDAS 4-6) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

Fluoride varnish and fissure sealant did not differ significantly in the proportion of children developing caries at 2 to 3 years (RR 1.12, 95% CI 0.60 to 2.09; 2 RCTs; ungraded).

1 finding from 1 review

CT + TT genotype (T-allele carriers) of AMELX rs2106416 vs CC genotype of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs2106416 and dental caries susceptibility (CT + TT vs CC model: OR 0.59, 95% CI 0.15-2.31) in the Age group: Children subgroup; certainty not graded.

3 findings from 1 review

G allele of LTF rs1126478 vs A allele of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between G allele vs A allele of LTF rs1126478 and dental caries susceptibility (G vs A model: OR 0.98, 95% CI 0.87-1.10); certainty not graded.

4 findings from 1 review
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