Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

444 questions · 453 findings · 34 reviews · Headline outcomes only

No studies found 117 · 25.8%GRADE not reported 17 · 3.8%Very low 176 · 38.9%Low 96 · 21.2%Moderate 34 · 7.5%High 13 · 2.9%

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Global outcome: general ‐ no improvement · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no improvement compared with OTHER ANTIPSYCHOTIC: f. PERPHENAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Adverse effect: Specific ‐ hypotensive episode · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effect: Specific ‐ hypotensive episode compared with OTHER ANTIPSYCHOTIC: f. PERPHENAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Adverse effect ‐ discontinued due to EPS · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effect ‐ discontinued due to EPS compared with OTHER ANTIPSYCHOTIC: f. PERPHENAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Specific behaviours ‐ agitation >50% reduction in PANSS‐EC score · patients with psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in specific behaviours ‐ agitation >50% reduction in PANSS‐EC score compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Global outcome ‐ rated as severe ‐ CGI‐S · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome ‐ rated as severe ‐ CGI‐S compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Adverse effects: specific ‐ acute dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ acute dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review