Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

480 questions · 494 findings · 38 reviews

No studies found 118 · 23.9%GRADE not reported 54 · 10.9%Very low 176 · 35.6%Low 99 · 20%Moderate 34 · 6.9%High 13 · 2.6%

HALOPERIDOL vs chlorpromazine

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ cardiovascular ‐ hypotension compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse effects: specific ‐ seizure · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ central nervous system ‐ seizures compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs PLACEBO/NIL

Repeated need for tranquillisation ‐ needing additional injections during 24 hours · patients with psychosis‐induced aggression or agitation

HALOPERIDOL may leads to lower repeated need for tranquillisation needing additional injection… compared with PLACEBO/NIL (low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

Tranquillisation or asleep ‐ not asleep up to 2 hours · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in tranquillisation or asleep ‐ not asleep up to 2 hours compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

Global outcome ‐ need for benzodiazepine during 24 hours · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in global outcome ‐ need for benzodiazepine compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

1 finding from 1 review