Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

537 questions · 560 findings · 45 reviews · Common Mental Disorders

No studies found 105 · 18.8%GRADE not reported 8 · 1.4%Very low 170 · 30.4%Low 153 · 27.3%Moderate 94 · 16.8%High 30 · 5.4%

Comparison 1: 5HT1A partial agonists vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

It is very uncertain whether comparison 1: 5HT1A partial agonists changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).

1 finding from 1 review

Levetiracetam vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 3: anticonvulsant levetiracetam changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

It is very uncertain whether comparison 4: antipsychotics changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 4: antipsychotics changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review

Benzodiazepines vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

Comparison 5: benzodiazepines may leads to higher global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (low certainty).

1 finding from 1 review

Benzodiazepines vs placebo

Withdrawals due to adverse events · adults with SAnD

It is very uncertain whether comparison 5: benzodiazepines changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).

1 finding from 1 review