Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

558 questions · 586 findings · 46 reviews · Pregnancy and Childbirth

No studies found 151 · 25.8%GRADE not reported 53 · 9%Very low 124 · 21.2%Low 157 · 26.8%Moderate 76 · 13%High 25 · 4.3%

Laxative vs placebo

Adverse effects on women: abdominal cramps · women in the postpartum period

Laxative may leads to higher adverse effects on women: abdominal cramps compared with placebo (low certainty).

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Mortality due to bleeding ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

One uterine devascularisation technique (uterine arterial embolisation) vs another uterine devascularisation technique (surgical devascularisation plus B‐Lynch)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · treating primary postpartum haemorrhage

The review found no eligible studies for this question.

1 finding from 1 review

One uterine devascularisation technique (uterine arterial embolisation) vs another uterine devascularisation technique (surgical devascularisation plus B‐Lynch)

Number of women with total blood loss 1000 mL or more after randomisation · treating primary postpartum haemorrhage

The review found no eligible studies for this question.

1 finding from 1 review

One uterine devascularisation technique (uterine arterial embolisation) vs another uterine devascularisation technique (surgical devascularisation plus B‐Lynch)

Blood transfusion (red cell or whole blood) · treating primary postpartum haemorrhage

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mortality due to bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes mortality due to bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Hysterectomy to control bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes hysterectomy to control bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Number of women with total blood loss 1000 mL or more after randomisation · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes number of women with total blood loss 1000 mL or more after… compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mean blood loss (mL) (trialist defined) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Blood transfusion (red cell or whole blood) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes blood transfusion (red cell or whole blood) compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade (latex balloon inflated with air) plus cerclage and normal care vs normal care

Hysterectomy to control bleeding · women with PPH, due to atony, following vaginal birth at home or in hospital (Soltan 2007)

It is very uncertain whether intrauterine balloon tamponade (latex balloon inflated with air)… changes hysterectomy to control bleeding compared with normal care (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade (latex balloon inflated with air) plus cerclage and normal care vs normal care

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women with PPH, due to atony, following vaginal birth at home or in hospital (Soltan 2007)

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade (latex balloon inflated with air) plus cerclage and normal care vs normal care

Number of women with total blood loss 1000 mL or more after randomisation · women with PPH, due to atony, following vaginal birth at home or in hospital (Soltan 2007)

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade (latex balloon inflated with air) plus cerclage and normal care vs normal care

Blood transfusion (red cell or whole blood) · women with PPH, due to atony, following vaginal birth at home or in hospital (Soltan 2007)

The review found no eligible studies for this question.

1 finding from 1 review