Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,359 questions · 2,491 findings · 249 reviews

No studies found 696 · 27.9%GRADE not reported 213 · 8.6%Very low 611 · 24.5%Low 595 · 23.9%Moderate 315 · 12.6%High 61 · 2.4%

Active stimulation + other intervention vs other intervention alone

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity (number of people with ≥ 50% improvement) · adults with chronic pain

Active stimulation + other intervention may leads to higher pain intensity. Proportion with ≥50% pain relief. compared with other intervention alone (low certainty).

2 findings from 1 review

NobelActive external connection implants vs NobelReplace implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive external connection implants showed no clear difference in implant failure compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

NobelActive internal connection implants vs NobelReplace implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive internal connection implants showed no clear difference in marginal bone level change compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

NobelActive external connection implants vs NobelReplace implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive external connection implants showed no clear difference in marginal bone level change compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

NobelActive internal connection implants vs Nobel Speedy Groovy external connection implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive internal connection implants led to lower marginal bone level change compared with nobel Speedy Groovy external connection implants; GRADE not reported.

1 finding from 1 review

NobelActive internal connection implants vs NobelReplace implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive internal connection implants showed no clear difference in implant failure compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

Placebo (sham irradiation, laser inactive) vs Control (no laser device used)

Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)

Placebo (sham irradiation, laser inactive) led to lower maximum pain (verbal rating scale, VRS) compared with control (no laser device used); GRADE not reported.

1 finding from 1 review

Active education + Support for implementation vs Routine care or Passive dissemination

Process outcome, Practitioner Impact 1. Polypharmacy at · patients with schizophrenia or related psychoses

It is very uncertain whether active education + Support for implementation changes process outcome, Practitioner Impact 1. Polypharmacy at compared with routine care or Passive dissemination (very low certainty).

1 finding from 1 review

Active education + Support for implementation vs Routine care or Passive dissemination

Process outcome, Practitioner Impact: 2. Not screened for cardiovascular risk, Framingham score (corrected for design effect) · patients with schizophrenia or related psychoses

It is very uncertain whether active education + Support for implementation changes process outcome, Practitioner Impact: 2. Not screened for… compared with routine care or Passive dissemination (very low certainty).

1 finding from 1 review