Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,447 questions · 2,590 findings · 266 reviews

No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

Intraoperative mortality or postoperative mortality: Death ( · children and adults undergoing surgery

Active cerebral oxygenation monitoring showed no clear difference in intraoperative mortality or postoperative mortality: Death ( compared with blinded cerebral oxygenation monitoring (low certainty).

1 finding from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Participant‐reported pain relief of 50% or greater · adults with chronic pain

It is very uncertain whether active stimulation + other intervention changes pain intensity. Proportion with ≥ 50% pain relief. compared with other intervention alone (very low certainty).

1 finding from 1 review

Active stimulation + other intervention vs other intervention alone

Adverse event: lead failure/ displacement · adults with chronic pain

The review found no eligible studies for this question.

3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity (number of people with ≥ 50% improvement) · adults with chronic pain

Active stimulation + other intervention may leads to higher pain intensity. Proportion with ≥50% pain relief. compared with other intervention alone (low certainty).

2 findings from 1 review

NobelActive external connection implants vs NobelReplace implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive external connection implants showed no clear difference in implant failure compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

NobelActive internal connection implants vs NobelReplace implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive internal connection implants showed no clear difference in marginal bone level change compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

NobelActive external connection implants vs NobelReplace implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive external connection implants showed no clear difference in marginal bone level change compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

NobelActive internal connection implants vs Nobel Speedy Groovy external connection implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive internal connection implants led to lower marginal bone level change compared with nobel Speedy Groovy external connection implants; GRADE not reported.

1 finding from 1 review

NobelActive internal connection implants vs NobelReplace implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive internal connection implants showed no clear difference in implant failure compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review