Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Intervention not reported

AEs: drug‐related AEs · children and adults with mucopolysaccharidosis type VI

It is very uncertain whether the intervention changes AEs: drug‐related AEs (very low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (cardiac) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (cardiac) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Gastrointestinal adverse events · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (gastrointestinal) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (bones and muscles) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (bones and muscles) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (others) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (others) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

All adverse effects · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in all adverse effects compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Paraesthesia · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in paraesthesia compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Dizziness · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in dizziness compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Headache · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in headache compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Anorexia · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in anorexia compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Rash · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in rash compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Gingival hyperplasia · participants with epilepsy (GTCS)

Sulthiame may leads to lower gingival hyperplasia compared with phenytoin (low certainty).

1 finding from 1 review