Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Intervention not reported

Early postoperative non‐thrombotic complications · Individuals with peripheral arterial disease

The intervention showed no clear difference in early postoperative non‐thrombotic complications (high certainty).

1 finding from 1 review

Intervention not reported

Procedural mortality · Individuals with peripheral arterial disease

The intervention showed no clear difference in procedural mortality (high certainty).

1 finding from 1 review

Intervention not reported

Clinical improvement · Individuals with peripheral arterial disease

The intervention showed no clear difference in clinical improvement (low certainty).

1 finding from 1 review

Intervention not reported

Amputation · Individuals with peripheral arterial disease

The intervention showed no clear difference in amputation (high certainty).

1 finding from 1 review

Intervention not reported

Primary patency · Individuals with peripheral arterial disease

The intervention probably leads to higher primary patency (moderate certainty).

1 finding from 1 review

Intervention not reported

Primary patency · Individuals with peripheral arterial disease

The intervention showed no clear difference in primary patency (high certainty).

1 finding from 1 review

Intervention not reported

Mortality within · Individuals with peripheral arterial disease

The intervention showed no clear difference in mortality within (high certainty).

1 finding from 1 review

LOD vs other surgical interventions

Harms: Adhesions at 6 months ‐ LOD vs THL N of participants: 246 (1 RCT) · Women with symptoms of PCOS

It is very uncertain whether LOD changes harms: Adhesions at 6 months ‐ LOD vs THL N of participants: 246 (1… compared with other surgical interventions (very low certainty).

1 finding from 1 review

LOD 4‐5 vs 2 or fewer punctures

Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS

LOD 4‐5 may leads to higher menstrual regularity at 6 months ‐ LOD 4 ‐ 5 coagulation points… compared with 2 or fewer punctures (low certainty).

2 findings from 1 review

LOD vs LOD variable energy

Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS

It is very uncertain whether LOD changes menstrual regularity at 3 months ‐ LOD unipolar vs LOD bipolar N of… compared with LOD variable energy (very low certainty).

1 finding from 1 review