Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intervention not reported

BEV+TRC 105 (1 RCT, 49 participants) · people with any recurrence of glioblastoma Interventions: bevacizumab (BEV) Comparison: bevacizumab 9BEV), BEV+carboplatin (CAB),…

The intervention leads to higher BEV+TRC 105 (1 RCT, 49 participants) (high certainty).

1 finding from 1 review

Intervention not reported

All intervention options · people with first recurrence of glioblastoma Interventions: bevacizumab (BEV), BEV + lomustine (LOM), regorafenib (REG), BEV + irinotecan…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

FOM (1 RCT, 32 participants) · people with any recurrence of glioblastoma Interventions: bevacizumab (BEV) Comparison: bevacizumab 9BEV), BEV+carboplatin (CAB),…

The intervention showed no clear difference in FOM (1 RCT, 32 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

BEV+HSPPC96 1 RCTs; 53 participants) · people with any recurrence of glioblastoma Interventions: bevacizumab (BEV) Comparison: bevacizumab 9BEV), BEV+carboplatin (CAB),…

The intervention showed no clear difference in BEV+HSPPC96 1 RCTs; 53 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV+ONA(1 RCT; 64 participants) · people with any recurrence of glioblastoma Interventions: bevacizumab (BEV) Comparison: bevacizumab 9BEV), BEV+carboplatin (CAB),…

The intervention showed no clear difference in BEV+ONA(1 RCT; 64 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV+CAB (1 RCT; 58 participants) · people with any recurrence of glioblastoma Interventions: bevacizumab (BEV) Comparison: bevacizumab 9BEV), BEV+carboplatin (CAB),…

The intervention showed no clear difference in BEV+CAB (1 RCT; 58 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV+DAS (2 RCTs, 83 participants) · people with any recurrence of glioblastoma Interventions: bevacizumab (BEV) Comparison: bevacizumab 9BEV), BEV+carboplatin (CAB),…

The intervention showed no clear difference in BEV+DAS (2 RCTs, 83 participants) (high certainty).

1 finding from 1 review