Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Treatment route: intravenous corticosteroid vs oral corticosteroid

Relapse Hospital readmission for COPD · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in relapse Hospital readmission for COPD compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

PEEP vs zero end‐expiratory pressure (ZEEP) during mechanical ventilation

Postoperative mortality · adult participants given general anaesthesia

It is very uncertain whether PEEP changes postoperative mortality compared with zero end‐expiratory pressure (ZEEP) during mechanical ventilation (very low certainty).

1 finding from 1 review

PEEP vs zero end‐expiratory pressure (ZEEP) during mechanical ventilation

Pneumonia · adult participants given general anaesthesia

It is very uncertain whether PEEP changes pneumonia compared with zero end‐expiratory pressure (ZEEP) during mechanical ventilation (very low certainty).

1 finding from 1 review

Tiotropium vs placebo

Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium leads to higher number of patients with a clinically significant improvement (≥ 4… compared with placebo (high certainty).

1 finding from 1 review

Tiotropium vs placebo

Number of patients with a clinically significant worsening (≥ 4 units) in quality of life (SGRQ) · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium leads to lower number of patients with a clinically significant worsening (≥ 4… compared with placebo (high certainty).

1 finding from 1 review

Tiotropium vs placebo

Exacerbations (number of people experiencing ≥ 1 exacerbations) · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium leads to lower number of patients with one or more exacerbations compared with placebo (high certainty).

1 finding from 1 review

Tiotropium vs placebo

Hospital admissions due to exacerbations: number of participants · people with COPD who have smoked for ≥ 10 pack‐years

Tiotropium showed no clear difference in number of patients with one or more exacerbations requiring… compared with placebo (moderate certainty).

1 finding from 1 review