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Evidence found and GRADE certainty

517 questions · 551 findings · 17 reviews · Oral Health

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No studies found 65 · 11.8%GRADE not reported 419 · 76%Very low 29 · 5.3%Low 25 · 4.5%Moderate 13 · 2.4%High 0 · 0%

Xanthum gum-containing spray (Xialine) vs Placebo spray

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Xanthum gum-containing spray (Xialine) showed no clear difference in xerostomia (EORTC dry mouth score) compared with placebo spray (base without xanthum); GRADE not reported.

1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Jellema 2001 (crossover, n=30, post-radiotherapy): no statistically significant difference between Xialine (xanthum gum) spray and placebo on the EORTC dry mouth score (Analysis 1.2). van der Reijden 1996: xanthum…
    2 studies · 30 participants
    GRADE not reported

Carboxymethylcellulose (CMC) spray vs Salinum linseed oil spray

Patient preference · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review

CMC spray / aloe vera gel / canola oil spray vs Mucin spray (and between each other)

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Momm 2005 (crossover, n=123): all four treatments significantly reduced dryness vs baseline (mean xerostomia score, scale 1 to 6: baseline 4.5 +/- 0.11; post-treatment aloe vera 3.7 +/- 0.11, CMC 3.8 +/- 0.12, canola…
    1 study · 123 participants
    GRADE not reported

Consumption of xylitol chewing gum by women (mothers) vs Profylin lozenge (xylitol/sorbitol + CMC)

Xerostomia (dry mouth relief) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Risheim 1993 (crossover, high risk of bias, n=18, rheumatic patients): both products gave good subjective relief of dry mouth in slightly less than one third of participants; crossover design not accounted for, no…
    1 study · 18 participants
    GRADE not reported

Oxygenated glycerol triester (OGT) spray vs Saliveeze (aqueous electrolyte) spray

Patient satisfaction · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Oxygenated glycerol triester (OGT) spray showed no clear difference in patient satisfaction compared with saliveeze (aqueous electrolyte) spray; GRADE not reported.

1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Mouly 2007b: patient satisfaction measured by VAS for global acceptability (Analysis 3.4); no significant difference between treatments for overall oral condition. Satisfaction for taste favoured OGT (mean VAS…
    1 study
    GRADE not reported

CMC/sorbitol pre-moistened swabs vs Lemon glycerin swabs

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Poland 1987 (crossover, high risk of bias, n=20): CMC/sorbitol reported superior to lemon glycerin for reducing oral dryness; brief report, incomplete data, period effect noted; not usable for meta-analysis.
    1 study · 20 participants
    GRADE not reported

Oral care protocol vs usual care or no treatment

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Oral care protocol showed no clear difference in oral mucositis (severe) compared with no treatment/usual care; GRADE not reported.

1 finding from 1 review

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

1 finding from 1 review

Mucin-containing lozenge vs placebo control

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Mucin-containing lozenge showed no clear difference in xerostomia (VAS mouth dryness) compared with placebo lozenge; GRADE not reported.

1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Gravenmade 1993 (crossover, high risk of bias, n=42, Sjogren's syndrome): no statistically significant difference between mucin lozenge and placebo for mouth dryness on a VAS (Analysis 1.2).
    1 study · 42 participants
    GRADE not reported

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) may leads to lower oral mucositis (any severity) compared with no treatment (low certainty).

1 finding from 1 review