Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

483 questions · 519 findings · 42 reviews · Headline outcomes only

No studies found 136 · 26.2%GRADE not reported 9 · 1.7%Very low 136 · 26.2%Low 150 · 28.9%Moderate 68 · 13.1%High 20 · 3.9%

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

Lost to treatment · people with both severe mental illness and substance misuse

It is very uncertain whether non‐integrated models of care ‐ Assertive community treatment… changes leaving the study early: Lost to treatment compared with standard care (very low certainty).

1 finding from 1 review

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

Adverse event: Death ‐ not measured · people with both severe mental illness and substance misuse

The review found no eligible studies for this question.

1 finding from 1 review