Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 6 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 6 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 12 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 12 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 18 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 18 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 24 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 24 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review