Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

577 questions · 585 findings · 77 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 143 · 24.4%GRADE not reported 26 · 4.4%Very low 145 · 24.8%Low 156 · 26.7%Moderate 98 · 16.8%High 17 · 2.9%

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Incidence of TIA · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes incidence of TIA compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes serious adverse events as a result of sickle cell‐related… compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

The review found no eligible studies for this question.

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Quality of life ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

The review found no eligible studies for this question.

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Stroke · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes clinical stroke compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

All‐cause mortality · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes all‐cause mortality compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Incidence of TIA · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes incidence of TIA compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes serious adverse events as a result of sickle cell‐related… compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

The review found no eligible studies for this question.

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Adverse events associated with transfusion · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

It is very uncertain whether long‐term red cell transfusion changes adverse events associated with transfusion compared with no transfusion (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

TIA · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

It is very uncertain whether long‐term red cell transfusion changes TIA compared with no transfusion (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

Long‐term red cell transfusion may leads to lower serious adverse events as a result of sickle cell‐related… compared with no transfusion (low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes clinical stroke compared with no transfusion (very low certainty).

1 finding from 1 review