Azoles vs placebo
Clinical cure · participants with confirmed toenail onychomycosis
Azole leads to higher clinical cure compared with placebo (high certainty).
1 finding from 1 review
- RR 22.18 [12.63, 38.95]9 studies · 3440 participantsHigh
Findings
What do systematic reviews say?
628 questions · 651 findings · 39 reviews · Skin
No studies found 167 · 25.7%GRADE not reported 47 · 7.2%Very low 80 · 12.3%Low 139 · 21.4%Moderate 174 · 26.7%High 44 · 6.8%
Azoles vs placebo
Mycological cure · participants with confirmed toenail onychomycosis
Azole leads to higher mycological cure compared with placebo (high certainty).
1 finding from 1 review
- RR 5.86 [3.23, 10.62]9 studies · 3440 participantsHigh
Azoles vs placebo
Adverse events · participants with confirmed toenail onychomycosis
Azole showed no clear difference in adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.04 [0.97, 1.12]9 studies · 3441 participantsModerate
Azoles vs placebo
Recurrence · participants with confirmed toenail onychomycosis
Azole showed no clear difference in recurrence rate compared with placebo (low certainty).
1 finding from 1 review
- RR 0.55 [0.29, 1.07]1 study · 26 participantsLow
Azoles vs placebo
Quality of life · participants with confirmed toenail onychomycosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Complete cure and adverse events for terbinafine vs placebo
Clinical cure · participants with confirmed toenail onychomycosis
Terbinafine leads to higher clinical cure compared with placebo (high certainty).
1 finding from 1 review
- RR 6 [3.96, 9.08]8 studies · 1006 participantsHigh
Complete cure and adverse events for terbinafine vs placebo
Mycological cure · participants with confirmed toenail onychomycosis
Terbinafine leads to higher mycological cure compared with placebo (high certainty).
1 finding from 1 review
- RR 4.53 [2.47, 8.33]8 studies · 1006 participantsHigh
Complete cure and adverse events for terbinafine vs placebo
Adverse events · participants with confirmed toenail onychomycosis
Terbinafine showed no clear difference in adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.13 [0.87, 1.47]4 studies · 399 participantsModerate
Complete cure and adverse events for terbinafine vs placebo
Recurrence · participants with confirmed toenail onychomycosis
Terbinafine may leads to lower recurrence rate compared with placebo (low certainty).
1 finding from 1 review
- RR 0.05 [0.01, 0.38]1 study · 35 participantsLow
Urea‐containing moisturisers vs vehicle, placebo or no moisturiser
Change from baseline in disease severity as assessed by the participants (number of participants who considered their skin to have improved) · people with eczema
Urea‐containing moisturisers may leads to higher change from baseline in disease severity according to the… compared with vehicle, placebo or no moisturiser (low certainty).
1 finding from 1 review
- RR 1.28 [1.06, 1.53]1 study · 129 participantsLow
Urea‐containing moisturisers vs vehicle, placebo or no moisturiser
Participant satisfaction · people with eczema
1 finding from 1 review
- no estimate extracted1 study · 38 participantsLow
Urea‐containing moisturisers vs vehicle, placebo or no moisturiser
Number of participants reporting an adverse event · people with eczema
Urea‐containing moisturisers probably leads to higher number of participants reporting an adverse event compared with vehicle, placebo or no moisturiser (moderate certainty).
1 finding from 1 review
- RR 1.65 [1.16, 2.34]1 study · 129 participantsModerate
Urea‐containing moisturisers vs vehicle, placebo or no moisturiser
Change from baseline in disease severity according to the investigators (number of participants who improved according to the investigators) · people with eczema
Urea‐containing moisturisers probably leads to higher change from baseline in disease severity according to the… compared with vehicle, placebo or no moisturiser (moderate certainty).
1 finding from 1 review
- RR 1.4 [1.14, 1.71]1 study · 129 participantsModerate
Urea‐containing moisturisers vs vehicle, placebo or no moisturiser
Number of participants who experienced a flare · people with eczema
Urea‐containing moisturisers may leads to lower number of participants who experienced a flare compared with vehicle, placebo or no moisturiser (low certainty).
1 finding from 1 review
- RR 0.47 [0.24, 0.92]1 study · 44 participantsLow
Urea‐containing moisturisers vs vehicle, placebo or no moisturiser
Change in use of topical active treatment ‐ not measured · people with eczema
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Urea‐containing moisturisers vs vehicle, placebo or no moisturiser
Change from baseline in health‐related quality of life ‐ not measured · people with eczema
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Glycerin/glycerol‐containing moisturisers vs vehicle or placebo
Change from baseline in disease severity as assessed by the participants(number of participants who considered their dry skin to have improved) · people with eczema
Glycerin/glycerol‐containing moisturisers probably leads to higher change from baseline in disease severity as assessed by the… compared with vehicle or placebo (moderate certainty).
1 finding from 1 review
- RR 1.22 [1.01, 1.48]1 study · 134 participantsModerate
Glycerin/glycerol‐containing moisturisers vs vehicle or placebo
Participant satisfaction ‐ not measured · people with eczema
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Glycerin/glycerol‐containing moisturisers vs vehicle or placebo
Number of participants reporting an adverse event · people with eczema
Glycerin/glycerol‐containing moisturisers showed no clear difference in number of participants reporting an adverse event compared with vehicle or placebo (moderate certainty).
1 finding from 1 review
- RR 0.9 [0.68, 1.19]2 studies · 385 participantsModerate
Glycerin/glycerol‐containing moisturisers vs vehicle or placebo
Change from baseline in disease severity as assessed by the investigators · people with eczema
1 finding from 1 review
- no estimate extracted1 study · 249 participantsHigh