Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

828 questions · 1,007 findings · 63 reviews · All outcomes

No studies found 110 · 10.9%GRADE not reported 709 · 70.4%Very low 84 · 8.3%Low 70 · 7%Moderate 33 · 3.3%High 1 · 0.1%

Low‐level laser therapy vs Low-level laser therapy (LLLT) + calcium hydroxide

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with low-level laser therapy (LLLT) + calcium hydroxide; GRADE not reported.

1 finding from 1 review

Diode laser + mineral trioxide aggregate (MTA) vs Formocresol (FC) + zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Diode laser + mineral trioxide aggregate (MTA) showed no clear difference in radiological failure compared with formocresol (FC) + zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) probably leads to lower clinical failure compared with calcium hydroxide (CH) (moderate certainty).

2 findings from 1 review

Zinc oxide and eugenol (ZOE) vs ZOE + calcium hydroxide + iodoform (MPRCF, unnamed product)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Zinc oxide and eugenol (ZOE) led to lower clinical failure compared with ZOE + calcium hydroxide + iodoform (unnamed product); GRADE not reported.

1 finding from 1 review

Biodentine vs Propolis

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in radiological failure compared with propolis; GRADE not reported.

1 finding from 1 review

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

1 finding from 1 review

OrthoMTA vs RetroMTA

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

OrthoMTA showed no clear difference in radiological failure compared with retroMTA; GRADE not reported.

1 finding from 1 review

Metapex (calcium hydroxide/iodoform) vs Endoflas chlorophenol free (Endoflas-CF)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with endoflas chlorophenol free (Endoflas-CF); GRADE not reported.

1 finding from 1 review

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

1 finding from 1 review