Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

374 questions · 377 findings · 63 reviews · Pregnancy and Childbirth

No studies found 88 · 23.3%GRADE not reported 32 · 8.5%Very low 92 · 24.4%Low 103 · 27.3%Moderate 50 · 13.3%High 12 · 3.2%

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Uterine hyperstimulation without fetal heart rate changes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation without FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Apgar score less than 7 at 5 minutes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes apgar score less than 7 at 5 minutes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Oral misoprostol vs placebo/no treatment

Uterine hyperstimulation without fetal heart rate changes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation without fetal heart rate changes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral misoprostol vs placebo/no treatment

Apgar score less than 7 at 5 minutes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes apgar score less than 7 at 5 minutes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Adverse events (maternal) ‐ skin irritation or allergic skin reaction · women undergoing caesarean section

It is very uncertain whether chlorhexidine gluconate changes adverse events (maternal) ‐ skin irritation or allergic skin reaction compared with povidone iodine (very low certainty).

1 finding from 1 review