Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

466 questions · 492 findings · 33 reviews · Common Mental Disorders

No studies found 136 · 27.6%GRADE not reported 7 · 1.4%Very low 147 · 29.9%Low 133 · 27%Moderate 58 · 11.8%High 11 · 2.2%

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

Diagnosis of PTSD after treatment · various

It is very uncertain whether any early psychological intervention changes PTSD diagnosis: post‐treatment compared with waiting list/usual care (very low certainty).

1 finding from 1 review

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

PTSD diagnosis · various

Any early psychological intervention may leads to lower PTSD diagnosis: 3–6 months compared with waiting list/usual care (low certainty).

2 findings from 1 review

Switching to mianserin (60 mg/d) vs continuing on current antidepressant (fluoxetine 20 mg/d)

Depressive symptoms · treatment‐resistant depression in adults

Switching to mianserin (60 mg/d) showed no clear difference in depressive symptoms (HAM‐D) Scale from: 0 to 54 (worse) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).

1 finding from 1 review