Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

541 questions · 556 findings · 112 reviews · Headline outcomes only

No studies found 130 · 23.4%GRADE not reported 22 · 4%Very low 156 · 28.1%Low 151 · 27.2%Moderate 72 · 12.9%High 25 · 4.5%

Thrombopoietin mimetics vs placebo or usual care

Number of participants with severe or life‐threatening bleeding · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether thrombopoietin mimetics changes number of participants with severe or life‐threatening bleeding compared with placebo or standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with at least 1 bleeding episode · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether the intervention changes number of participants with at least 1 bleeding episode (very low certainty).

1 finding from 1 review

Intervention not reported

Combined mortality of all studies · Adult patients in intensive care

The intervention leads to higher combined mortality of all studies (high certainty).

1 finding from 1 review