Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,247 questions · 1,321 findings · 334 reviews

No studies found 73 · 5.5%GRADE not reported 31 · 2.3%Very low 500 · 37.9%Low 406 · 30.7%Moderate 247 · 18.7%High 64 · 4.8%

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi with chemotherapy vs chemotherapy alone

Adverse events (grade ≥ 3) · newly‐diagnosed EOC

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi with… leads to higher any severe adverse event (grade 3 or higher) (G3+ SevAE) compared with chemotherapy alone (high certainty).

1 finding from 1 review

Mobility training vs control: subgroups with or without cognitive impairments

Level of functioning · older people living in the community with frailty
2 findings from 1 review

Mobility training vs control: subgroups with or without cognitive impairments

Mobility · older people living in the community with frailty
2 findings from 1 review

Laser therapy vs no treatment

Scar severity ‐ 585‐nm Pulsed‐Dye Laser (PDL) versus no treatment ‐ patient self‐assessment of scar improvement of 50% or higher ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars

Laser therapy may leads to higher scar severity ‐ 585‐nm Pulsed‐Dye Laser (PDL) versus no treatment ‐… compared with no treatment (low certainty).

1 finding from 1 review

Laser therapy vs no treatment

Scar severity ‐ 585‐nm Pulsed‐Dye Laser (PDL) versus Triamcinolone acetonide (TAC) ‐ Vancouver Burn Scar (VBS) (Higher score = worse scar appearance) ‐ hypertrophic scars ‐ · participants with hypertrophic and keloid scars
2 findings from 1 review

Laser therapy vs other treatments

Scar severity ‐ 585‐nm PDL versus TAC ‐ patient self‐assessment of scar improvement of 50% or higher, or patients considering the scar better or much better ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars

It is very uncertain whether laser therapy changes scar severity ‐ 585‐nm PDL versus TAC ‐ patient self‐assessment of… compared with other treatments (very low certainty).

1 finding from 1 review