Findings

What do systematic reviews say?

534 questions · 539 findings · 63 reviews · Pregnancy and Childbirth

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No studies found 101 · 18.7%GRADE not reported 63 · 11.7%Very low 93 · 17.3%Low 167 · 31%Moderate 89 · 16.5%High 26 · 4.8%

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Caesarean section · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to higher caesarean section compared with low‐dose oral misoprostol (moderate certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 1.17 [1.04, 1.32]
7 studies · 3178 participants
Moderate

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Serious neonatal morbidity or perinatal death · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in serious neonatal morbidity or perinatal death compared with low‐dose oral misoprostol (low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 1.11 [0.6, 2.06]
3 studies · 2627 participants
Low

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Serious maternal morbidity or death · third trimester induction of labour in women with a viable fetus

It is very uncertain whether balloon (Foley or ATAD) changes serious maternal morbidity or death compared with low‐dose oral misoprostol (very low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.5 [0.05, 5.52]
3 studies · 2627 participants
Very low

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Uterine hyperstimulation with fetal heart rate changes · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to lower uterine hyperstimulation with FHR changes compared with vaginal prostaglandin E2 (moderate certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.35 [0.18, 0.67]
6 studies · 1966 participants
Moderate

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Apgar score less than 7 at 5 minutes · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in apgar score < 7 after 5 minutes compared with low‐dose oral misoprostol (low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.71 [0.38, 1.32]
4 studies · 2693 participants
Low

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Admission to neonatal intensive care unit · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in neonatal intensive care unit admission compared with low‐dose oral misoprostol (low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.82 [0.58, 1.17]
5 studies · 2873 participants
Low

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Caesarean section · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in caesarean section compared with vaginal prostaglandin E2 (moderate certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 1 [0.92, 1.09]
28 studies · 6619 participants
Moderate

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Serious neonatal morbidity or perinatal death · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to lower serious neonatal morbidity or perinatal death compared with vaginal prostaglandin E2 (moderate certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.48 [0.25, 0.93]
8 studies · 2757 participants
Moderate

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Serious maternal morbidity or death · third trimester induction of labour in women with a viable fetus

It is very uncertain whether balloon (Foley or ATAD) changes serious maternal morbidity or death compared with vaginal prostaglandin E2 (very low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.2 [0.01, 4.12]
4 studies · 1481 participants
Very low

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Apgar score less than 7 at 5 minutes · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in apgar score < 7 at 5 minutes compared with vaginal prostaglandin E2 (low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.74 [0.49, 1.14]
14 studies · 4271 participants
Low

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Admission to neonatal intensive care unit · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in neonatal intensive care unit admission compared with vaginal prostaglandin E2 (low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.82 [0.65, 1.04]
12 studies · 3647 participants
Low

Balloon (Foley or ATAD) vs low‐dose vaginal misoprostol

Vaginal delivery not achieved within 24 hours · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in vaginal delivery not achieved in 24 hours compared with low‐dose vaginal misoprostol (low certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 1.09 [0.85, 1.39]
2 studies · 340 participants
Low

Balloon (Foley or ATAD) vs low‐dose vaginal misoprostol

Uterine hyperstimulation with fetal heart rate changes · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to lower uterine hyperstimulation with FHR changes compared with low‐dose vaginal misoprostol (moderate certainty).

1 finding from 1 review

Mechanical methods for induction of labour 2023 · Cochrane Headline outcomes only
RR 0.39 [0.18, 0.85]
8 studies · 1322 participants
Moderate

Amniotic membranes sweeping vs no treatment/sham

Spontaneous onset of labour · pregnant women carrying a live fetus at or near term (≥ 36 weeks' gestation).

Amniotic membranes sweeping may leads to higher spontaneous onset of labour compared with no treatment/sham (low certainty).

1 finding from 1 review

Membrane sweeping for induction of labour 2020 · Cochrane Headline outcomes only
RR 1.21 [1.08, 1.34]
17 studies · 3170 participants
Low

Amniotic membranes sweeping vs vaginal/intracervical prostaglandins

Caesarean section · pregnant women carrying a live fetus at or near term (≥ 36 weeks' gestation).

Amniotic membranes sweeping showed no clear difference in caesarean section compared with vaginal/intracervical prostaglandins (low certainty).

1 finding from 1 review

Membrane sweeping for induction of labour 2020 · Cochrane Headline outcomes only
RR 0.69 [0.44, 1.09]
3 studies · 339 participants
Low

Amniotic membranes sweeping vs vaginal/intracervical prostaglandins

Spontaneous vaginal birth · pregnant women carrying a live fetus at or near term (≥ 36 weeks' gestation).

Amniotic membranes sweeping showed no clear difference in spontaneous vaginal birth compared with vaginal/intracervical prostaglandins (low certainty).

1 finding from 1 review

Membrane sweeping for induction of labour 2020 · Cochrane Headline outcomes only
RR 1.12 [0.95, 1.32]
2 studies · 252 participants
Low

Amniotic membranes sweeping vs vaginal/intracervical prostaglandins

Serious maternal morbidity or death · pregnant women carrying a live fetus at or near term (≥ 36 weeks' gestation).

Amniotic membranes sweeping showed no clear difference in maternal death or serious maternal morbidity compared with vaginal/intracervical prostaglandins (low certainty).

1 finding from 1 review

Membrane sweeping for induction of labour 2020 · Cochrane Headline outcomes only
RR 0.93 [0.27, 3.21]
1 study · 87 participants
Low

Amniotic membranes sweeping vs vaginal/intracervical prostaglandins

Neonatal death or serious neonatal perinatal morbidity · pregnant women carrying a live fetus at or near term (≥ 36 weeks' gestation).

Amniotic membranes sweeping showed no clear difference in neonatal death or serious neonatal perinatal morbidity compared with vaginal/intracervical prostaglandins (low certainty).

1 finding from 1 review

Membrane sweeping for induction of labour 2020 · Cochrane Headline outcomes only
RR 0.4 [0.12, 1.33]
2 studies · 269 participants
Low

Amniotic membranes sweeping vs intravenous oxytocin/amniotomy

Spontaneous onset of labour · pregnant women carrying a live fetus at or near term (≥ 36 weeks' gestation).

Amniotic membranes sweeping showed no clear difference in spontaneous onset of labour compared with intravenous oxytocin/amniotomy (low certainty).

1 finding from 1 review

Membrane sweeping for induction of labour 2020 · Cochrane Headline outcomes only
RR 1.32 [0.88, 1.96]
1 study · 69 participants
Low

Amniotic membranes sweeping vs intravenous oxytocin/amniotomy

Induction of labour · pregnant women carrying a live fetus at or near term (≥ 36 weeks' gestation).

Amniotic membranes sweeping showed no clear difference in induction of labour compared with intravenous oxytocin/amniotomy (low certainty).

1 finding from 1 review

Membrane sweeping for induction of labour 2020 · Cochrane Headline outcomes only
RR 0.51 [0.05, 5.42]
1 study · 69 participants
Low