What do systematic reviews say?

Intervention not reported

It is very uncertain whether the intervention changes total length of hospital stay (days) (very low certainty).

• Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery 2023 · Cochrane Headline outcomes only
  MD 0.99
  2 studies · 371 participants
  Very low

Intervention not reported

• Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery 2023 · Cochrane Headline outcomes only
  1.34 [0.72, 2.48]
  3 studies · 323 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes postoperative mortality (very low certainty).

• Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery 2023 · Cochrane Headline outcomes only
  Peto OR 0.24 [0.05, 1.06]
  5 studies · 517 participants
  Very low

Vaginal procedure vs sacral colpopexy (vault prolapse)

Vaginal procedure probably leads to higher awareness of prolapse compared with sacral colpopexy (vault prolapse) (moderate certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 2.31 [1.27, 4.21]
  4 studies · 346 participants
  Moderate

Vaginal hysterectomy vs sacral hysteropexy/cervicopexy (uterine prolapse)

Vaginal hysterectomy showed no clear difference in prolapse on examination (Stage 2 or greater) ‐ Any recurrent prolapse compared with sacral hysteropexy/cervicopexy (uterine prolapse) (moderate certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 0.78 [0.54, 1.11]
  2 studies · 230 participants
  Moderate

Vaginal hysterectomy vs sacral hysteropexy/cervicopexy (uterine prolapse)

It is very uncertain whether vaginal hysterectomy changes mesh exposure compared with sacral hysteropexy/cervicopexy (uterine prolapse) (very low certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 1.85 [0.7, 4.87]
  4 studies · 307 participants
  Very low

Vaginal hysterectomy vs sacral hysteropexy/cervicopexy (uterine prolapse)

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 422 participants
  Low

Vaginal hysterectomy vs sacral hysteropexy/cervicopexy (uterine prolapse)

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 422 participants
  Very low

Vaginal hysterectomy vs sacral hysteropexy/cervicopexy (uterine prolapse)

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 148 participants
  Low

Vaginal hysteropexy vs sacral hysteropexy (uterine prolapse)

Vaginal hysteropexy showed no clear difference in awareness of prolapse compared with sacral hysteropexy (uterine prolapse) (low certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 0.55 [0.21, 1.44]
  1 study · 257 participants
  Low

Vaginal hysteropexy vs sacral hysteropexy (uterine prolapse)

Vaginal hysteropexy showed no clear difference in prolapse on examination (Stage 2 or above) ‐ Any recurrent prolapse compared with sacral hysteropexy (uterine prolapse) (moderate certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 0.99 [0.83, 1.19]
  2 studies · 367 participants
  Moderate

Vaginal hysteropexy vs sacral hysteropexy (uterine prolapse)

It is very uncertain whether vaginal hysteropexy changes mesh exposure (1‐4 years) compared with sacral hysteropexy (uterine prolapse) (very low certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 7.05 [0.37, 135.2]
  1 study · 257 participants
  Very low

Vaginal hysteropexy vs sacral hysteropexy (uterine prolapse)

Vaginal hysteropexy showed no clear difference in painful intercourse ‐ De novo dyspareunia compared with sacral hysteropexy (uterine prolapse) (moderate certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 1.86 [0.72, 4.83]
  2 studies · 203 participants
  Moderate

Vaginal hysteropexy vs sacral hysteropexy (uterine prolapse)

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 209 participants
  Low

Vaginal hysterectomy vs vaginal hysteropexy (uterine prolapse)

Vaginal hysterectomy showed no clear difference in awareness of prolapse compared with vaginal hysteropexy (uterine prolapse) (moderate certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 1 [0.44, 2.24]
  2 studies · 365 participants
  Moderate

Vaginal hysterectomy vs vaginal hysteropexy (uterine prolapse)

Vaginal hysterectomy showed no clear difference in prolapse on examination (Stage 2 or above) ‐ Any recurrent prolapse compared with vaginal hysteropexy (uterine prolapse) (low certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 1.44 [0.79, 2.61]
  2 studies · 361 participants
  Low

Vaginal hysterectomy vs vaginal hysteropexy (uterine prolapse)

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 413 participants
  Low

Vaginal hysterectomy vs vaginal hysteropexy (uterine prolapse)

Vaginal hysterectomy showed no clear difference in bladder function ‐ Stress incontinence compared with vaginal hysteropexy (uterine prolapse) (low certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  OR 0.51 [0.22, 1.17]
  1 study · 175 participants
  Low

Vaginal hysterectomy vs vaginal hysteropexy (uterine prolapse)

Vaginal hysterectomy showed no clear difference in painful intercourse ‐ Dyspareunia compared with vaginal hysteropexy (uterine prolapse) (low certainty).

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  RR 0.53 [0.13, 2.11]
  2 studies · 331 participants
  Low

Vaginal hysterectomy vs vaginal hysteropexy (uterine prolapse)

• Surgery for women with apical vaginal prolapse 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 382 participants
  Low