Findings

What do systematic reviews say?

4,756 questions · 11,779 findings · 747 reviews · Headline outcomes only

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No studies found 3,205 · 27.2%GRADE not reported 628 · 5.3%Very low 3,261 · 27.7%Low 2,913 · 24.7%Moderate 1,453 · 12.3%High 319 · 2.7%

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Lesinurad 400 mg plus febuxostat CROSS vs lesinurad 200 mg plus febuxostat CROSS

Mean sUA at end of 12 months · participants with tophi in gout

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 67 participants
Low

Pegloticase every two weeks (biweekly) vs placebo

Quality of life ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pegloticase every two weeks (biweekly) vs placebo

Serum urate normalisation ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pegloticase every two weeks (biweekly) vs placebo

Function ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pegloticase every two weeks (biweekly) vs placebo

Withdrawals due to adverse events · participants with tophi in gout

Pegloticase every two weeks (biweekly) probably leads to higher number of participant withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
RR 7.59 [1.04, 55.55]
1 study · 128 participants
Moderate

Pegloticase every two weeks (biweekly) vs placebo

Total adverse events · participants with tophi in gout

Pegloticase every two weeks (biweekly) showed no clear difference in total adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
RR 0.99 [0.91, 1.07]
1 study · 128 participants
Moderate

Monthly pegloticase vs placebo

Proportion with complete resolution of a target tophus · participants with tophi in gout

Monthly pegloticase showed no clear difference in proportion with complete resolution of tophi compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
RR 2.86 [0.68, 11.97]
1 study · 79 participants
Moderate

Monthly pegloticase vs placebo

Joint pain reduction ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Peer support vs usual care

Confidence and self‐efficacy · parents and carers of children with complex needs

1 finding from 1 review

Peer support interventions for parents and carers of children with complex needs 2021 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 542 participants
Low

Peer support vs usual care

Perception of coping · parents and carers of children with complex needs

1 finding from 1 review

Peer support interventions for parents and carers of children with complex needs 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 293 participants
Very low

Quality of life Measures: ‐ Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ) ‐ Beach Centre Family Quality of Life Scale (higher scores = better quality of life) Timing of · parents and carers of children with complex needs

1 finding from 1 review

Peer support interventions for parents and carers of children with complex needs 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 143 participants
Very low

Peer support vs usual care

Family functioning · parents and carers of children with complex needs

1 finding from 1 review

Peer support interventions for parents and carers of children with complex needs 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 272 participants
Very low

Peer support vs usual care

Perceived social support · parents and carers of children with complex needs

1 finding from 1 review

Peer support interventions for parents and carers of children with complex needs 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 191 participants
Very low

Peer support vs usual care

Confidence and skill at navigating medical services · parents and carers of children with complex needs

1 finding from 1 review

Peer support interventions for parents and carers of children with complex needs 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Peer support vs usual care

Adverse events · parents and carers of children with complex needs

The review found no eligible studies for this question.

1 finding from 1 review

Peer support interventions for parents and carers of children with complex needs 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Registration behaviour: ICC adjusted (dichotomous) · increasing solid organ donation registration

The intervention may leads to higher registration behaviour: ICC adjusted (dichotomous) (low certainty).

1 finding from 1 review

Interventions for increasing solid organ donor registration 2021 · Cochrane Headline outcomes only
RR 1.3 [1.19, 1.43]
16 studies · 1294065 participants
Low

Intervention not reported

Registration intention (dichotomous) · increasing solid organ donation registration intention

The intervention may leads to higher registration intention (dichotomous) (low certainty).

1 finding from 1 review

Interventions for increasing solid organ donor registration 2021 · Cochrane Headline outcomes only
RR 1.21 [1.03, 1.42]
10 studies · 10838 participants
Low

Intervention not reported

Registration intention: ICC adjusted (continuous) · increasing solid organ donor registration

1 finding from 1 review

Interventions for increasing solid organ donor registration 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 3572 participants
Low

Heparin vs placebo

Early graft thrombosis · kidney transplant recipients

1 finding from 1 review

Interventions for preventing thrombosis in solid organ transplant recipients 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Heparin vs placebo

Major bleeding events: unfractionated heparin · kidney transplant recipients

Heparin showed no clear difference in major bleeding events: unfractionated heparin compared with placebo (low certainty).

1 finding from 1 review

Interventions for preventing thrombosis in solid organ transplant recipients 2021 · Cochrane Headline outcomes only
RR 2.92 [0.89, 9.56]
3 studies · 155 participants
Low