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Evidence found and GRADE certainty

418 questions · 611 findings · 68 reviews

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No studies found 88 · 14.4%GRADE not reported 237 · 38.8%Very low 74 · 12.1%Low 115 · 18.8%Moderate 87 · 14.2%High 10 · 1.6%

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in neonatal mortality compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in treatment failure compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in adverse events compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with fast breathing alone

Comparison 2: 7 days oral amoxicillin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with fast breathing alone

Comparison 2: 7 days oral amoxicillin showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ first dose and referral · neonates with sepsis

Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).

1 finding from 1 review