Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

444 questions · 453 findings · 34 reviews · Headline outcomes only

No studies found 117 · 25.8%GRADE not reported 17 · 3.8%Very low 176 · 38.9%Low 96 · 21.2%Moderate 34 · 7.5%High 13 · 2.9%

HALOPERIDOL vs chlorpromazine

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ cardiovascular ‐ hypotension compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse effects: specific ‐ seizure · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ central nervous system ‐ seizures compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs PLACEBO/NIL

Repeated need for tranquillisation ‐ needing additional injections during 24 hours · patients with psychosis‐induced aggression or agitation

HALOPERIDOL may leads to lower repeated need for tranquillisation needing additional injection… compared with PLACEBO/NIL (low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

Tranquillisation or asleep ‐ not asleep up to 2 hours · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in tranquillisation or asleep ‐ not asleep up to 2 hours compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

1 finding from 1 review