Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

402 questions · 411 findings · 41 reviews

No studies found 99 · 24.1%GRADE not reported 32 · 7.8%Very low 132 · 32.1%Low 112 · 27.3%Moderate 33 · 8%High 3 · 0.7%

Synbiotic vs placebo

Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation

Synbiotics may leads to higher global improvement or treatment success, as defined by primary study compared with placebo (low certainty).

1 finding from 1 review

Synbiotics and paraffin vs paraffin

Global assessment of treatment success · children with chronic constipation without a physical explanation

It is very uncertain whether synbiotics and paraffin changes global improvement or treatment success, as defined by primary studies compared with paraffin (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation

Probiotic may leads to higher global improvement/treatment success as defined by primary study compared with placebo (low certainty).

1 finding from 1 review