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Evidence found and GRADE certainty

346 questions · 375 findings · 54 reviews · Effective Practice and Organisation of Care

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No studies found 84 · 22.4%GRADE not reported 18 · 4.8%Very low 93 · 24.8%Low 103 · 27.5%Moderate 62 · 16.5%High 15 · 4%

Intervention not reported

Serum concentrations ‐ aminoglycoside antibiotics: peak concentration · patients with leading serum concentrations within therapeutic range
1 finding from 1 review

Intervention not reported

Death · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in death (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ bleeding · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in anticoagulants: events ‐ bleeding (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ thromboembolism · patients with leading to fewer clinical adverse events

It is very uncertain whether the intervention changes anticoagulants: events ‐ thromboembolism (very low certainty).

1 finding from 1 review

Intervention not reported

Insulin ‐ hypoglycaemia (< 60 mg/dL) · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in insulin ‐ hypoglycaemia (< 60 mg/dL) (low certainty).

1 finding from 1 review

Intervention not reported

Insulin ‐ severe hypoglycaemia (< 40 mg/dL) · patients with leading to fewer clinical adverse events

It is very uncertain whether the intervention changes insulin ‐ severe hypoglycaemia (< 40 mg/dL) (very low certainty).

1 finding from 1 review

Intervention not reported

Aminoglycoside antibiotics ‐ nephrotoxicity · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in aminoglycoside antibiotics ‐ nephrotoxicity (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants within therapeutic range ‐ aminoglycoside antibiotics: % of participants with peak concentrations adequate after 2 days · patients with leading serum concentrations within therapeutic range

The intervention probably leads to higher proportion of participants within therapeutic range ‐ aminoglycoside… (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants with toxic drug levels ‐ theophylline · patients with leading serum concentrations within therapeutic range

The intervention showed no clear difference in proportion of participants with toxic drug levels ‐ theophylline (moderate certainty).

1 finding from 1 review

Intervention not reported

Oral anticoagulants: time in target INR range (%) · patients with leading physiological parameters within therapeutic range
1 finding from 1 review