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Evidence found and GRADE certainty

458 questions · 466 findings · 48 reviews · Schizophrenia

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No studies found 87 · 18.7%GRADE not reported 82 · 17.6%Very low 153 · 32.8%Low 111 · 23.8%Moderate 19 · 4.1%High 14 · 3%

Any antiglucocorticoid vs placebo

Quality of life: improved to an important degree · people with psychosis
3 findings from 1 review

Any antiglucocorticoid vs placebo

Global state: general ‐no clinically significant improvement ‐ data only for mifepristone < 30% improvement on BPRS · people with psychosis

It is very uncertain whether any antiglucocorticoid changes global state: general ‐no clinically significant improvement ‐ data… compared with placebo (very low certainty).

1 finding from 1 review

Any antiglucocorticoid vs placebo

Adverse effects: 1. General ‐ overall number of events · people with psychosis

Any antiglucocorticoid probably leads to higher adverse effects: 1. General ‐ overall number of events compared with placebo (moderate certainty).

2 findings from 1 review

Any antiglucocorticoid vs placebo

Global state: 1. General ‐ no clinically significant improvement ‐ short term < 30% improvement on BPRS · people with psychosis

Any antiglucocorticoid may leads to lower global state: 1. General ‐ no clinically significant improvement ‐… compared with placebo (low certainty).

1 finding from 1 review

Any antiglucocorticoid vs placebo

Global state: 2. Specific: positive ‐ no clinically significant improvement ‐ short term (< 50% improvement on BPRS PSS) · people with psychosis

Any antiglucocorticoid may leads to lower global state: 2. Specific: positive ‐ no clinically significant… compared with placebo (low certainty).

1 finding from 1 review