Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

586 questions · 621 findings · 22 reviews · Oral medicine and oral cancer

No studies found 94 · 15.1%GRADE not reported 377 · 60.7%Very low 103 · 16.6%Low 35 · 5.6%Moderate 11 · 1.8%High 1 · 0.2%

Acupuncture vs sham

Unstimulated whole saliva (UWS) · Adults with dry mouth due to radiotherapy (head and neck cancer) or Sjogren's Syndrome

Acupuncture may leads to higher unstimulated whole saliva (UWS) compared with placebo (sham acupuncture) (low certainty).

2 findings from 1 review

Electrostimulation (device) vs Placebo (sham/placebo device)

Stimulated whole saliva (SWS) · Adults with dry mouth due to Sjogren's Syndrome

It is very uncertain whether electrostimulation (device) changes stimulated whole saliva (SWS) compared with placebo (sham/placebo device) (very low certainty).

1 finding from 1 review

Acupuncture vs sham

Stimulated whole saliva (SWS) · Adults with dry mouth due to radiotherapy (head and neck cancer) or Sjogren's Syndrome

Acupuncture may leads to higher stimulated whole saliva (SWS) compared with placebo (sham acupuncture) (low certainty).

2 findings from 1 review

Electrostimulation (device) vs Placebo (sham/placebo device)

Unstimulated whole saliva (UWS) · Adults with dry mouth due to Sjogren's Syndrome

It is very uncertain whether electrostimulation (device) changes unstimulated whole saliva (UWS) compared with placebo (sham/placebo device) (very low certainty).

1 finding from 1 review

Acupuncture vs sham

Adverse events · Adults with dry mouth due to radiotherapy (head and neck cancer) or Sjogren's Syndrome
1 finding from 1 review

Multivitamin vs placebo

Average mouth pain during RAS episodes · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in average mouth pain during RAS episodes compared with placebo; GRADE not reported.

1 finding from 1 review

Levamisole (150 mg per day) vs placebo

Decrease in frequency of attacks · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Levamisole (150 mg per day) showed no clear difference in decrease in frequency of attacks compared with placebo; GRADE not reported.

1 finding from 1 review

Levamisole (150 mg per day) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo

Time to resolution of first ulcer (days) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Prednisone (oral, commencing 25 mg with phased dose reduction over 2… led to lower time to resolution of first ulcer (days) compared with placebo; GRADE not reported.

1 finding from 1 review

Bee propolis (one 500 mg capsule per day) vs placebo

Quality of life · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Levamisole (150 mg per day) vs placebo

Effectiveness · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Mean VAS pain per day · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in mean VAS pain per day compared with placebo; GRADE not reported.

1 finding from 1 review