What do systematic reviews say?

Oral viscous budesonide vs swallowed fluticasone

Oral viscous budesonide showed no clear difference in histological improvement at study endpoint (dichotomous) compared with swallowed fluticasone (low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 1.13 [0.84, 1.51]
  1 study · 129 participants
  Low

Oral viscous budesonide vs swallowed fluticasone

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 111 participants
  Low

Oral viscous budesonide vs swallowed fluticasone

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral viscous budesonide vs swallowed fluticasone

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 111 participants
  Low

Oral viscous budesonide vs swallowed fluticasone

Oral viscous budesonide showed no clear difference in withdrawals due to adverse events at 8 weeks compared with swallowed fluticasone (low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.42, 2.32]
  1 study · 129 participants
  Low

Corticosteroids vs placebo

Corticosteroids showed no clear difference in endoscopic improvement (dichotomous) compared with placebo (low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 2.6 [0.82, 8.19]
  3 studies · 102 participants
  Low

Esomeprazole vs fluticasone

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Esomeprazole vs fluticasone

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 67 participants
  Very low

Esomeprazole vs fluticasone

It is very uncertain whether esomeprazole changes histological improvement at 8 weeks (dichotomous) compared with fluticasone (very low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 1.62 [0.77, 3.41]
  2 studies · 72 participants
  Very low

Esomeprazole vs fluticasone

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 70 participants
  Very low

Esomeprazole vs fluticasone

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Esomeprazole vs fluticasone

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Esomeprazole vs fluticasone

It is very uncertain whether esomeprazole changes withdrawals due to adverse events at 8 weeks compared with fluticasone (very low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 0.95 [0.07, 13.38]
  2 studies · 72 participants
  Very low

One‐food elimination diet vs four‐food elimination diet

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

One‐food elimination diet vs four‐food elimination diet

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Very low

One‐food elimination diet vs four‐food elimination diet

It is very uncertain whether one‐food elimination diet changes histological improvement at 12 weeks (dichotomous) compared with four‐food elimination diet (very low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 2.26 [1.15, 4.43]
  1 study · 63 participants
  Very low

Corticosteroids vs placebo

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 596 participants
  Low

One‐food elimination diet vs four‐food elimination diet

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

One‐food elimination diet vs four‐food elimination diet

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

One‐food elimination diet vs four‐food elimination diet

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Very low