Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

748 questions · 782 findings · 58 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 164 · 21%GRADE not reported 26 · 3.3%Very low 151 · 19.3%Low 222 · 28.4%Moderate 158 · 20.2%High 61 · 7.8%

Probiotics vs other active intervention

Grade ≥ 3 diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics may leads to lower severity of diarrhoea: grade 3 or higher compared with other active treatment (low certainty).

1 finding from 1 review

Probiotics vs other active intervention

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

It is very uncertain whether probiotics changes requiring rescue medication for diarrhoea compared with other active treatment (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Median (mean) time to use of rescue medication · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics showed no clear difference in requiring rescue medication for diarrhoea compared with placebo (moderate certainty).

2 findings from 1 review

Probiotics vs placebo

Adverse events · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review