Leaving the study early ‐ short term ‐ due to lack of efficacy · patients with schizophrenia
It is very uncertain whether levomepromazine changes leaving the study early ‐ short term ‐ due to lack of efficacy compared with atypical antipsychotics (very low certainty).
1 finding from 1 review
Leaving the study early ‐ short term ‐ due to patient deterioration · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ due to patient deterioration compared with atypical antipsychotics (moderate certainty).
1 finding from 1 review
Leaving the study early ‐ short term ‐ lost to · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ lost to compared with atypical antipsychotics (low certainty).
1 finding from 1 review
Leaving the study early ‐ short term ‐ due to lack of efficacy · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ due to lack of efficacy compared with typical antipsychotics (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ due to adverse events compared with typical antipsychotics (low certainty).
1 finding from 1 review
Leaving the study early ‐ medium term ‐ any reason · patients with schizophrenia
It is very uncertain whether levomepromazine changes leaving the study early ‐ medium term ‐ any reason compared with typical antipsychotics (very low certainty).
1 finding from 1 review
Acceptability of treatment ‐ leaving the study early · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ long term ‐ any reason compared with typical antipsychotics (moderate certainty).
1 finding from 1 review
Leaving the study early ‐ long term ‐ due to adverse events · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ long term ‐ due to adverse events compared with typical antipsychotics (moderate certainty).
1 finding from 1 review
Leaving the study early ‐ long term ‐ lost to · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ long term ‐ lost to compared with typical antipsychotics (moderate certainty).
1 finding from 1 review
Behaviour: Leaving the study early (short‐term) · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ any reason compared with atypical antipsychotics (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with schizophrenia
Levomepromazine showed no clear difference in leaving the study early ‐ short term ‐ due to adverse events compared with atypical antipsychotics (moderate certainty).
1 finding from 1 review
Relapse · patients with schizophrenia
CLOZAPINE probably leads to lower relapse ‐ short term compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).
4 findings from 1 review
RR 0.62 [0.45, 0.84]
19 studies · 1303 participants
Moderate
RR 0.22 [0.14, 0.34]
4 studies · 578 participants
Moderate
RR 1.04 [0.61, 1.78]
4 studies · 396 participants
Moderate
Show 1 more finding
Global state: no improvement ‐ medium termAs defined in each study · patients with schizophrenia
CLOZAPINE probably leads to lower global impression: 1. Not clinically improved ‐ short term compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).
3 findings from 1 review
RR 0.71 [0.64, 0.79]
4 studies · 370 participants
Moderate
RR 0.83 [0.76, 0.91]
2 studies · 648 participants
Moderate
RR 0.72 [0.66, 0.79]
14 studies · 1119 participants
Moderate
Adverse effects 1. Blood problems · patients with schizophrenia
CLOZAPINE showed no clear difference in adverse effects 1. Blood problems compared with TYPICAL ANTIPSYCHOTICS; GRADE not reported.
1 finding from 1 review
Adverse effects 4. Salivation ‐ too much · patients with schizophrenia
CLOZAPINE probably leads to higher adverse effects 4. Salivation ‐ too much compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).
2 findings from 1 review
Weight gain · patients with schizophrenia
CLOZAPINE probably leads to higher adverse effects 5. Weight gain compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).
2 findings from 1 review
Unable to work · patients with schizophrenia
CLOZAPINE showed no clear difference in unable to work compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).
1 finding from 1 review
Adverse effects: 1. Blood problems ‐ decreased white cell count · patients with schizophrenia
CLOZAPINE probably leads to higher adverse effects: 1. Blood problems ‐ decreased white cell count compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).
1 finding from 1 review
Clinically important change in positive symptoms · schizophrenia spectrum disorders with catatonic symptoms
1 finding from 1 review
Clinically important change in negative symptoms · schizophrenia spectrum disorders with catatonic symptoms
1 finding from 1 review